ArcticLAS offers pre-clinical in vivo Pharmacokinetic and Pharmocodynamic studies.

ArcticLAS is a well established animal research facility and has experience in a variety of in vivo research models in mice and rats.
We offer administration of test compounds to mice and rats, various routs of administration and choice of sample collection. We also offer custom protocol development and consulting. 
Fast turnaround and effective communication improves customer’s involvement in the experiment and we focus on being flexible to meet sudden changes that can be expected in field of drug development.

Studies:

Pharmacokinetic (PK)

Is a process by which a drug is absorbed, distributed, metabolized and eliminated by a body.
Pharmacokinetic is therefore a key requirement in the evaluation of new chemical entities. A quantitative measure of drug exposure is always needed for interpretation of preclinical efficacy studies.
Standard drug efficacy testing can be performed in a variety of rodent models using protocols supplied by you, or developed by us.
We provide both fast, fixed and ready solutions for pharmacokinetic studies as well as studies tailored on customer’s request.
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Rat and Mouse MTD

Our staff will work with you to customize programs which can include Maximum Tolerated dose (MTD), as well as PK studies.
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ADME

Absorption, Distribution, Metabolism and Excretion.
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Pharmacodynamic

In contrast to pharmacokinetic, pharmacodynamic tells us what the drug does to the body.  It referst to the relationship between the drug and its concentration at the side of the action and the resulting effect, including the time course and intensity of therapeutic and adverse effects.
 

Diabetics models

Primary screening and dose response studies:  ArcticLAS offers dose response studies with evaluation of the effect of test compounds on blood glucose and body weight.
 

Blood pressure measurements – Tail-cuff method

Blood pressure measurements using Non-Invasive Blood Pressure System - Tail Cuff Method.  Measuring 6 blood pressure parameters: systolic, diastolic and mean blood pressure, heart rate, tail blood volume and blood flow.
 

Collagen induced arthritis

The collagen-induced arthritis (CIA) mouse model is the most commonly studied autoimmune model of rheumatoid arthritis. Autoimmune arthritis is induced in this model by immunization with an emulsion of complete Freund's adjuvant and type II collagen (CII).
 

Conditioned taste aversion, CTA

,,Conditioned taste aversion” is used to estimate if compound produce discomfort to animals.
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Oncology:

Oncology using immunocompromised animas that requires barrier unit.
 

Surgical models

Wide experience in models requiring simple surgical procedures.